Knight died on Thursday in Los Angeles, according to The Hollywood Reporter. The comedian's cause of death has not been disclosed.
Knight's family requests privacy during this difficult time, a spokesman said.
Knight's career was taking off as his most recent Peacock production, "Bust Down," aired in March. The sitcom was co-created, executive produced, and starred in by Knight.
He has contributed to blockbuster shows such as Netflix's "Big Mouth" and ABC's "Black-ish."
Following the devastating news of his demise, his peers expressed their sympathies.
On Friday, Comedy Central took to Twitter and remarked, "Jak Knight was a hilarious and sincere comedian. We will miss him terribly."
"We are heartbroken by the passing of Jak Knight," said Peacock's "Bust Down" and Universal Television in a joint statement to the Hollywood Reporter.
In a tribute tweet, comedian Eddie Della Siepe labelled Knight a "phenom." "An fantastic skill and, more importantly, a wonderful person," he continued.
Knight thanked Dave Chappelle for encouraging his career in comedy in a 2018 interview with Respect. "Those are the only reasons I do what I do," he stated at the time.
During the same interview, Knight talked about writing and voicing DeVon in the successful show "Big Mouth."